- Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
R Rodriguez; K M Miller; J V Forment; C R Bradshaw; M Nikan; S Britton; T Oelschlaegel; B Xhemalce; S Balasubramanian; S P Jackson
Nat. Chem. Biol., Advanced Article,
DOI: 10.1038/nchembio.780(2012)
PDF - FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA
P Sarkies; P Murat; L G Phillips; K J Patel; S Balasubramanian; J E Sale
Nucleic Acids Research, Advanced Article,
DOI: 10.1093/nar/gkr882(2011)
PDF - A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro
E Raiber; R Kranaster; E Lam; M Nikan; S Balasubramanian
Nucleic Acids Research, Advanced Article,
DOI: 10.1093/nar/gkr882
PDF - Synthesis of Bis-indole Carboxamides as G-Quadruplex Stabilizing and Inducing Ligands
J Dash; R N Das; N Hegde; G D Pantoş; P Shirude; S Balasubramanian
Chem. European Journal, 18 (2), 554-64 (2012)
DOI: 10.1002/chem.201102556
PDF - Demonstration of Ligand Decoration, and Ligand-Induced Perturbation, of G-Quadruplexes in a Plasmid Using Atomic Force Microscopy
I Mela; R Kranaster; R M Henderson; S Balasubramanian and J M Edwardson
Biochemistry, 51 (2), 578–585 (2012)
DOI: 10.1021/bi201600g
PDF - Decoding genomes at high speed: implications for science and medicine
S Balasubramanian
Angew. Chem. Int. Ed, 50 (52), 12406-12410 (2011)
DOI: 10.1002/anie.201106707 (2011)
PDF - A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands
D Koirala, S Dhakal, B Ashbridge, Y Sannohe, R Rodriguez, H Sugiyama, S Balasubramanian and H Mao
Nature Chemistry, 3, 782-787 (2011)
DOI: 10.1038/nchem.1126
PDF - The transcription factor FOXM1 is a cellular target of the natural product thiostrepton
N S Hegde, D A Sanders, R Rodriguez and S Balasubramanian
Nature Chemistry, 3, 725-731 (2011)
DOI: 10.1038/nchem.1114
PDF - A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing
H L Lightfoot, A Bugaut, J Armisen, N J Lehrbach, E A Miska and S Balasubramanian
Biochemistry, 50, 7514-7521 (2011)
DOI: 10.1021/bi200851d
PDF - A Sequence-Independent Analysis of the Loop Length Dependence of Intramolecular RNA G-Quadruplex Stability and Topology
A Zhang, A Bugaut and S Balasubramanian
Biochemistry, 50, 7251-7258 (2011)
DOI: 10.1021/bi200805j
PDF - Sequencing nucleic acids: from chemistry to medicine
S Balasubramanian
RSC Chem. Commun., 47 (26), 7281-7286 (2011)
DOI:10.1039/c1cc11078k Highlight
PDF - Targeting G‐quadruplexes in gene promoters: a novel anticancer strategy?
S Balasubramanian, L H Hurley and S Neidle
Nature Reviews Drug Discovery, 10, 261-275 (2011)
DOI:10.1038/nrd3428
PDF - Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae
J S Smith, Q Chen, L A Yatsunyk, J M Nicoludis, M S Garcia, R Kranaster, S Balasubramanian, D Monchaud, M Teulade-Fichou, L Abramowitz, D C Schultz and F B Johnson
Nature Structural & Molecular Biology, 18, 478-485 (2011)
DOI: 10.1038/nsmb.2033
PDF - Synthesis and Binding Studies of Novel Diethynyl-pyridine Amides with Genomic Promoter DNA G-quadruplexes
J Dash, ZA E Waller, G D Pantos and S Balasubramanian
Chem. European Journal, 17, 4571-4581 (2011)
DOI: 10.1002/chem.201003157
PDF - G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulate c-KIT Expression in Human Gastric Carcinoma Cells
K I E McLuckie, Z A E Waller, D A Sanders,D Alves,R Rodriguez, J Dash, G J McKenzie, A R Venkitaraman and S Balasubramanian
J. Am. Chem. Soc. 133,2658–2663 (2011)
DOI: 10.1021/ja109474c
PDF - Small-molecule-mediated G-quadruplex isolation from human cells
S Muller, S Kumari, R Rodriguez and S Balasubramanian
Nature Chemistry, 2, 1095-1098 (2010)
DOI: 10.1038/NCHEM.842
PDF - Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines
M Bejugam, M Gunaratnam, S Mueller, D A Sanders, S Sewitz, J A Fletcher, S Neidle and S Balasubramanian
ACS Med. Chem. Lett. 1, 306–310 (2010)
DOI: 10.1021/ml100062z
PDF - Distinct functions of maternal and somatic Pat1 protein paralogs
A Marnef, M Maldonado, A Bugaut, S Balasubramanian, M Kress, D Weil and N Standart
RNA, 16, 2094–2107 (2010)
DOI: 10.1261/rna.2295410
PDF - The BCL-2 50 Untranslated Region Contains an RNA G-Quadruplex-Forming Motif that Modulates Protein Expression
R Shahid, A Bugaut and S Balasubramanian
Biochemistry, 49, 8300–8306 (2010)
DOI: 10.1021/bi100957h
PDF - Small Molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
A Bugaut, R Rodriguez, S-T D Hsu and S Balasubramanian
Org. Biomol. Chem., 8, 2771-2776 (2010)
DOI: 10.1039/c002418j
PDF - RNA Conformation in Catalytically Active Human Telomerase
J A Yeoman, A Orte, B Ashbridge, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 132, 2852-2853 (2010)
DOI: 10.1021/ja909383n
PDF - Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes
A Fegan, P S Shirude, L Ying and S Balasubramanian
Chem.Commun. 46,946-948 (2010)
DOI: 10.1039/b920680a
PDF - Single-Molecule Analysis of the Human Telomerase RNA·Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations
B Ashbridge, A Orte, J A Yeoman, M Kirwan, T Vulliamy, I Dokal, D Klenerman and S Balasubramanian
Biochemistry, 48, 10858-10865 (2009)
DOI: 10.1021/bi901373e
PDF - Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression
H Fernando, S Sewitz, J Darot, S Tavaré, J L Huppert and S Balasubramanian
Nucleic Acids Research, 37, 6716-6722 (2009)
DOI: 10.1093/nar/gkp740
PDF - LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
N J Lehrbach, J Armisen, H L Lightfoot, K J Murfitt, A Bugaut, S Balasubramanian and E A Miska
Nature Structural & Molecular Biology, 16, 1016-1020 (2009)
DOI:10.1038/nsmb.1675
PDF - A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics
S T Hsu, P Varnai, A Bugaut, A P Reszka, S Neidle and S Balasubramanian
J. Am. Chem. Soc., 131, 13399-409 (2009)
DOI: 10.1021/ja904007p
PDF - G-quadruplex DNA bound by a synthetic ligand is highly dynamic
P V Jena, P S Shirude, B Okumus, K Laxmi-Reddy, F Godde, I Huc, S Balasubramanian and T Ha
J. Am. Chem. Soc., 131, 12522-3 (2009)
DOI: 10.1021/ja903408r
PDF - A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression
Z A Waller, S A Sewitz, S T Hsu and S Balasubramanian
J. Am. Chem. Soc., 131, 12628-33 (2009)
DOI: 10.1021/ja901892u
PDF - G-quadruplex nucleic acids as therapeutic targets
S Balasubramanian and S Neidle
Current Opinion in Chemical Biology, 13, 345-353 (2009)
DOI: 10.1016/j.cbpa.2009.04.637
PDF - Controlled-folding of a small molecule modulates DNA G-quadruplex recognition
S Muller, G Dan Pantos, R Rodriguez and S Balasubramanian
Chem.Commun., 80-82 (2009)
DOI: b816861.j
PDF - Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
J E Redman, J M Granadino-Roldán, J A Schouten, S Ladame, A P Reszka, S Neidle and S Balasubramanian
Org. Biomol. Chem., 7, 76-84 (2009)
DOI: b814682a
PDF - FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts
T B C London, L J Barber, G Mosedale, G P Kelly, S Balasubramanian, I D Hickson, S J Boulton and K Hiom
J. Biol. Chem., 283, 36132-36139 (2008)
DOI: 10.1074/jbc.M808152200
PDF - Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5' UTR of the NRAS Proto-oncogene
S Kumari, A Bugaut and S Balasubramanian
Biochemistry, 47, 12664-12669 (2008)
DOI: 10.1038/nchembio864
PDF - Diarylethynyl Amides That Recognize the Parallel Conformation of Genomic Promoter DNA G-Quadruplexes
J Dash, P S Shirude, S-T D Hsu and S Balasubramanian
J. Am. Chem. Soc., 130, 15950-15956 (2008)
DOI: 10.1021/ja8046552
PDF - A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres
R Rodriguez, S Muller, J A Yeoman, C Trentesaux, J-F Riou and S Balasubramanian
J. Am. Chem. Soc., 130, 15758-15759 (2008)
DOI: 10.1021/ja805615w
PDF - Accurate whole human genome sequencing using reversible terminator chemistry
D R Bentley, S Balasubramanian, H P Swerdlow et al
Nature, 456, 53-59 (2008)
DOI: 10.1038/nature07517
PDF - G-quadruplexes: the beginning and end of UTRs
J L Huppert, A Bugaut, S Kumari and S Balasubramanian
Nucleic Acids Res., 36, 6260-6268 (2008)
DOI: 10.1093/nar/gkn511
PDF - Selective Recognition of a DNA G-Quadruplex by an Engineered Antibody
H Fernando, R Rodriguez and S Balasubramanian
Biochemistry, 47, 9365-9371 (2008)
DOI: 10.1021/bi800983u
PDF - Single molecule conformational analysis of DNA G-quadruplexes
P S Shirude and S Balasubramanian
Biochimie, 90, 1197-1206 (2008)
DOI: 10.1039/b801465e
PDF - G-quadruplex recognition by bis-indole carboxamides
J Dash, P S Shirude and S Balasubramanian
Chem. Commun., 3055-3057 (2008)
DOI: 10.1039/b806042h
PDF - Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC
P S Shirude, L Ying and S Balasubramanian
Chem. Commun., 2007-2009 (2008)
DOI: 10.1039/b801465e
PDF - Rigid cyanine dye nucleic acid labels
A Fegan, P S Shirude and S Balasubramanian
Chem. Commun., 2004-2006 (2008)
DOI: 10.1039/b801629a
PDF - Single-molecule analysis of human telomerase monomer
D Alves, H Li, R Codrington, A Orte, X Ren, D Klenerman and S Balasubramanian
Nature Chem.Biol., 4, 287-289 (2008)
DOI: 10.1038/nchembio.82
PDF - Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry
A Bugaut, K Jantos, J-L Wietor, R Rodriguez, J K M Sanders and S Balasubramanian
Angew. Chem. Int. Ed., 47, 2677-2680 (2008)
DOI: 10.1002/anie.200705589
PDF - Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition
Z Waller, P Shirude, R Rodriguez and S Balasubramanian
Chem. Commun., 1467-1469 (2008)
DOI: 10.1039/b718854d
PDF - A Sequence-Independent Study of the Influence of Short Loop Lengths on the Stability and Topology of Intramolecular DNA G-Quadruplexes
A Bugaut and S Balasubramanian
Biochemistry, 47, 689-697 (2008)
DOI: 10.1021/bi701873c
PDF - Trisubstituted Isoalloxazines as a New Class of G-Quadruplex Binding Ligands: Small Molecule Regulation of c-kit Oncogene Expression
M Bejugam, S Sewitz, P S Shirude, R Rodriguez, R Shahid and S Balasubramanian
J. Am. Chem. Soc., 129, 12926-12927 (2007)
DOI: 10.1021/ja075881p
PDF - Macrocyclic and Helical Oligoamides as a New Class of G-Quadruplex Ligands
P S Shirude, E R Gillies, S Ladame, F Godde, K Shin-ya, I Huc and S Balasubramanian
J. Am. Chem. Soc. 129, 11890-11891 (2007)
DOI: 10.1021/ja073775h
PDF - Ligand-Driven G-Quadruplex Conformational Switching By Using an Unusual Mode of Interaction
R Rodriguez, G Dan Pantos, D P N Goncalves, J K M Sanders and S Balasubramanian
Angew. Chem. Int. Ed., 46, 5404-5407 (2007)
DOI: 10.1002/anie.20060507
PDF - Single-Molecule Conformational Analysis of G-Quadruplex Formation in the Promoter DNA Duplex of the Proto-Oncogene C-Kit
P S Shirude, B Okumus, L Ying, T Ha and S Balasubramanian
J. Am. Chem. Soc., 129, 7484-7485 (2007)
DOI: 10.1021/ja070497d
PDF - An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation
S Kumari, A Bugaut, J L Huppert and S Balasubramanian
Nature Chem. Biol., 3, 218-221 (2007)
DOI: 10.1038/nchembio864
PDF - G-quadruplexes in promoters throughout the human genome
J L Huppert and S Balasubramanian
Nucleic Acids Res., 35, 2, 406-413 (2007)
DOI: 10.1093/nar/gkm109
PDF - Determination of the Fraction and Stoichiometry of Femtomolar Levels of Biomolecular Complexes in an Excess of Monomer Using Single-Molecule, Two-Color Coincidence Detection
A Orte, R Clarke, S Balasubramanian and D Klenerman
Anal. Chem., 78, 7707-7715 (2006) - Tetramethylpryidiniumporphyrazines - a new class of G-quadruplex inducing and stabilising ligands
D P Goncalves, R Rodriguez, S Balasubramanian and J K M Sanders
Chem. Commun., 4685-4687 (2006) - Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library
J E Redman, S Ladame, A P Reszka, S Neidle and S Balasubramanian
Org. Biomol. Chem., 4, 4364-4369 (2006) - A Simple Nanomixer for Single-Molecule Kinetics Measurements
S S White, S Balasubramanian, D Klenerman and L Ying
Angew. Chem. Int. Ed., 45 7540-7543 (2006) - Structural Analysis of the Catalytic Core of Human Telomerase RNA by FRET and Molecular Modeling
G Gavory, M F Symmons, Y Krishnan Ghosh, D Klenerman and S Balasubramanian
Biochemistry, 45, 13304-13311 (2006) - Oxazole-Based Peptide Macrocycles: A New Class of G-Quadruplex Binding Ligands
K Jantos, R Rodriguez, S Ladame, P S Shirude and S Balasubramanian
J. Am. Chem. Soc., 128, 13662-13663 (2006) - Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins
D P N Goncalves, S Ladame, S Balasubramanian and J K M Sanders
Org. Biomol. Chem., 4, 3337-3342 (2006) - Investigating a quadruplex-ligand interaction by unfolding kinetics
J J Green, S Ladame, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 126, 9809-9812 (2006) - A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene
H Fernando, A P Reszka, J Huppert, S Ladame, S Rankin, A R Venkitaraman, S Neidle and S Balasubramanian
Biochemistry, 45, 7854-7860 (2006) - Analysis of Human Telomerase Activity and Function by Two Color Single Molecule Coincidence Fluorescence Spectroscopy
X Ren, H Li, R W Clarke, D A Alves, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 128, 4992-5000 (2006) - Exploring the Recognition of Quadruplex DNA by an Engineered Cys2-His2 Zinc Finger Protein
S Ladame, J A Schouten, J Roldan, J E Redman, S Neidle and S Balasubramanian
Biochemistry, 45, 1393-1399 (2006) - A Reversible pH-Driven DNA Nanoswitch Array
D Liu, A Bruckbauer, C Abell, S Balasubramanian, D-J Kang, D Klenerman and D Zhou
J. Am. Chem. Soc., 128, 2067-2071 (2006) - DNA molecular motor driven micromechanical cantilever arrays
W Shu, D Liu, M Watari, C K Riener, T Strunz, M E Welland, S Balasubramanian and R McKendry
J. Am. Chem. Soc., 127, 17054-17060 (2005) - PNA forms an i-motif
Y Krishnan-Ghosh, E Stephens and S Balasubramanian
Chem. Commun., 5278-5280 (2005) - Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach
S Ladame, A Whitney and S Balasubramanian
Angew. Chem. Intl. Ed., 44, 5736-5739 (2005) - Putative DNA quadruplex formation within the human c-kit oncogene
S Rankin, A P Reszka, J Huppert, M Zloh, G N Parkinson, A K Todd, S Ladame, S Balasubramanian and S Neidle
J. Am. Chem. Soc., 127, 10584-10589 (2005) - Dynamic Covalent Chemistry on Self-Templating PNA Oligomers: Formation of a Bimolecular PNA Quadruplex
Y Krishnan-Ghosh, A Whitney and S Balasubramanian
Chem. Commun., 3068-3070 (2005) - Prevalence of quadruplexes in the human genome
J L Huppert and S Balasubramanian
Nucleic Acids Res., 33, 2908-2916 (2005) - Solid-phase methods for the synthesis of cyanine dyes
S Mason, J Hake, J Nairne, E J Cummins and S Balasubramanian
J. Org. Chem., 70, 2939-2949 (2005) - Loop-length dependent folding of G-quadruplexes
P Hazel, J Huppert, S Balasubramanian and S Neidle
J. Am. Chem. Soc., 126, 16405-16415 (2004) - Individual molecules of dye-labeled DNA act as a reversible two-colour switch upon application of an electric field
S S White, L Ying, S Balasubramanian and D Klenerman
Angew. Chem. Intl. Ed., 43, 5926-5930 (2004) - Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes
S D Patel, M Isalan, G Gavory, S Ladame, Y Choo and S Balasubramanian
Biochemistry, 43, 13452-13458 (2004) - Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform
S Ladame, J A Schouten, J Stuart, J Roldan, S Neidle and S Balasubramanian
Org. Biomol. Chem., 2, 2925-2931 (2004) - Measuring Single Molecule Nucleic Acid Dynamics in Solution by Two-Color Filtered Ratiometric Fluorescence Correlation Spectroscopy
H Li, X Ren, S Balasubramanian and D Klenerman
Proc. Natl. Acad. Sci. USA, 101, 14425-14430 (2004) - Formation of an Interlocked Quadruplex Dimer by d(GGGT)
Y Krishnan-Ghosh, D Liu and S Balasubramanian
J. Am. Chem. Soc., 125, 11009-11016 (2004) - Studies on the chemical stability and synthetic utility of an oxazolidine linker for solid-phase chemistry
A J Wills, M Cano and S Balasubramanian
J. Org. Chem., 69, 5439-47 (2004) - Molecule by molecule direct and quantitative counting of antibody complexes in solution
H Li, L Ying, S Balasubramanian and D Klenerman
Anal. Chem., 76, 4446-51 (2004) - A PNA4 Quadruplex
Y Krishnan-Ghosh, E Stephens and S Balasubramanian
J. Am. Chem. Soc., 126, 5944-5945 (2004) - Targeting the Single-Stranded Overhang of Telomeres with PNA Inhibits Cell Growth and Induces Apoptosis of Human Immortal Cells
M A Shammas, X Liu, G Gavory, K D Raney, S Balasubramanian and R J Shmookler Reis
Experimental Cell Research, 295, 204-214 (2004) - Templated Ligand Assembly using G-quadruplex DNA and Dynamic Covalent Chemistry
A Whitney, S Ladame and S Balasubramanian
Angew. Chem. Intl. Ed., 43, 1143-1146 (2004) - From the combinatorial chemistry boom to polymer-supported parallel chemistry: established technologies for drug discovery
M Cano and S Balasubramanian
Drugs of the Future, 28, 659-678 (2003) - Studies on the Structure and Dynamics of the Human Telomeric Quadruplex by Single Molecule Fluorescence Resonance Energy Transfer
L Ying, J J Green, H Li, D Klenerman and S Balasubramanian
Proc. Natl. Acad. Sci. USA, 100, 14629-14634 (2003) - A proton fuelled DNA nanomachine
D Liu and S Balasubramanian
Angew. Chem. Intl. Ed., 42, 5734-5736 (2003) - Identification of a new RNA*RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenital point mutation
X Ren, G Gavory, H Li, L Ying, D Klenerman and S Balasubramanian
Nucleic Acids Res., 31, 6509-6515 (2003) - Recent Developments in Linker Design and Application
A J Wills and S Balasubramanian
Curr. Op. Chem. Biol., 7, 346-352 (2003) - G-Quadruplex-Specific Peptide-Hemicyanine Ligands by Partial Combinatorial Selection
J A Schouten, S Ladame, S J Mason, M A Cooper and S Balasubramanian
J. Am. Chem. Soc., 125, 5594-5595 (2003) - Dynamic Covalent Chemistry on Self-Templating Peptides: Formation of a Disulphide-linked ?-Hairpin Mimic
Y Krishnan-Ghosh and S Balasubramanian
Angew. Chem. Intl. Ed., 42, 2171-2173 (2003) - Ultrasensitive coincidence fluorescence detection of single DNA molecules
H Li, L Ying, J J Green, S Balasubramanian and D Klenerman
Anal. Chem., 75, 1664-1670 (2003) - Kinetics of Unfolding the Human Telomeric DNA Quadruplex using a PNA Trap
J Green, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 125, 3763-3767 (2003) - Site-Specific Cleavage of Human Telomerase RNA using PNA-Neocuproine*Zn(II) derivatives
A Whitney, G Gavory and S Balasubramanian
Chem. Commun. 36-37 (2003) - PNA and oligonucleoide inhibitors of human telomerase
G Gavory and S Balasubramanian
Telomerases, Telomeres and Cancer Eds. G Krupp and R Parwaresch 67-80, Landes Bioscience: Austin (2003) - Solid phase catch-activate and release synthesis of cyanine dyes
S J Mason and S Balasubramanian
Org. Lett., 4, 4261-62 (2002) - Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro
G Gavory, M Farrow and S Balasubramanian
Nucleic Acids Res., 30, 4470-4480 (2002) - Synthesis of a polymer supported oxazolidine aldehyde for asymmetric chemistry
A J Wills, Y Krishnan-Ghosh and S Balasubramanian
J. Org. Chem. 67, 6646-6652 (2002) - Enhanced cooperative binding of oligonucleotides to form DNA duplexes mediated by metal ion chelation
I Horsey, Y Krishnan-Ghosh and S Balasubramanian
Chem. Commun., 14, 1950-51 (2002) - Solid phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates
S Ladame, R J Harrison, S Neidle and S Balasubramanian
Org. Lett., 4, 2509-2512 (2002) - Synthesis of diastereomerically pure 1,4,5-substituted-2-oxopiperazines on solid-phase
N M Khan, M Cano and S Balasubramanian
Tetrahedron Lett., 43, 2439-2443 (2002) - Studies on the chemical stability and functional group compatibility of the Benzoin Photolabile Safety-catch (BPSC) linker using an analytical construct
M Cano, M Ladlow and S Balasubramanian
J. Combinatorial Chemistry, 4, 44-48 (2002) - Practical synthesis of a dithiane protected 3',5'-dialkyoxybenzoin photolabile safety-catch linker (BPSC) for solid phase organic synthesis
M Cano, M Ladlow and S Balasubramanian
J. Org. Chem., 67, 129-135 (2002) - Solid Phase Chemical Technologies for Combinatorial Chemistry
S Balasubramanian
J. Cell. Biochem. Suppl., 37, 28-33 (2001) - Non-Arrhenius kinetics of a DNA Hairpin-Loop
L Ying, M I Wallace, S Balasubramanian and D Klenerman
Proc. Natl. Acad. Sci. USA, 98, 5584-5589 (2001) - Probing DNA surface attachment and local environment using single molecule spectroscopy
M A Osborne, C L Barnes, S Balasubramanian and D Klenerman
J. Phys. Chem. B, 105, 3120-3126 (2001) - Exploring a Benzyloxyaniline Linker Utilizing Ceric Ammonium Nitrate (CAN) as a Cleavage Reagent: Solid-Phase Synthesis of N-Unsubstituted Beta-Lactams and Secondary Amides
K Gordon and S Balasubramanian
Org. Lett., 3, 53-56 (2001) - Selection of Zinc Fingers that Bind Single-Stranded Telomeric DNA in the G-Quadruplex Conformation
M Isalan, S D Patel, S Balasubramanian and Y Choo
Biochemistry, 40, 830-836 (2001) - The Science of chemical discovery: probing the unknown with new technologies
S Balasubramanian
Drug Discovery Today, vol.5, 12, 533-534 (2000) - FRET Fluctuation Spectroscopy: Exploring the Conformational Dynamics of a DNA Hairpin Loop
M I Wallace, L Ying, S Balasubramanian and D Klenerman
J. Phys. Chem. B, 104, 11551-11555 (2000) - A stereoselective synthesis of 1,3,4-substituted -lactams from polymer-supported chiral oxazolidine aldehyde
K Gordon, M Bolger, N Khan and S Balasubramanian
Tetrahedron Lett., 41, 8621-8625 (2000) - Strategies for the synthesis of fluorescently labelled PNA
X Liu and S Balasubramanian
Tetrahedron Lett., 41, 6153-6156 (2000) - Double Fluorescence Resonance Energy Transfer to Explore Multicomponent Binding Interactions: A Case Study of DNA Mismatches
I Horsey, W S Furey, J G Harrison, M A Osborne and S Balasubramanian
Chem. Commun., 12, 1043-1044 (2000) - Single Molecule Analysis of DNA Immobilised on Microspheres
M A Osborne, W S Furey, D Klenerman and S Balasubramanian
Anal. Chem., 72, 3678-3681 (2000) - Ratiometric analysis of single-molecule fluorescence resonance energy transfer using logical combinations of threshold criteria: A study of 12-mer DNA
L Ying, M I Wallace, S Balasubramanian and D Klenerman
J. Phys Chem B, 104, 5171-5178 (2000) - Recent Developments in the Encoding and Deconvolution of Combinatorial Libraries
C L Barnes and S Balasubramanian
Current Opinion in Chemical Biology, 4, 346-350 (2000) - Solid Phase Preparation of Tertiary Amides and 1,2,4,5-Tetrasubstituted Imidazoles Using a Traceless Cleavage Strategy Based on Benzylic Acyl Ammonium Chloride Reactivity
H B Lee and S Balasubramanian
Org. Lett., 2, 323-326 (2000) - Screening for Oligonucleotide Binding Affinity by a Convenient Fluorescence Competition Assay
J G Harrison, X Liu and S Balasubramanian
Nucleic Acids Research, 27 e14 (1999) - Thermodynamic Melting Studies on Oligonucleotide-Peptide Conjugates
C Frier, J G Harrison and S Balasubramanian
Nucleosides and Nucleotides, 18 1477-1478 (1999) - Solid Phase Synthesis: Designer Linkers for Combinatorial Chemistry
K Gordon and S Balasubramanian
J. Chem. Tech. Biotech., 74, 835-851(1999) - Recent Advances in Solid-Phase Chemical Methodologies
K Gordon and S Balasubramanian
Current Opinion in Drug Discover and Development 2, 342-349 (1999) - Exploring a Chemical Encoding Strategy for Combinatorial Synthesis using Friedels-Craft Alkylation
R H Scott, C Barnes, U Gerhard and S Balasubramanian
Chem Commun. 1331-1332 (1999) - Inhibition of Human Telomerase by PNA- Cationic Peptide Conjugates
J G Harrison, C Frier, R Laurant, K D Raney and S Balasubramanian
Bioorg. Med. Chem. Lett., 9, 1273-1278 (1999) - Studies on Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid Phase Synthesis
H B Lee and S Balasubramanian
J. Org. Chem., 64, 3454-3460 (1999); 64, 5728 (legend correction) (1999) - Progress in Chemical Encoding for Combinatorial Synthesis
C Barnes, R H Scott and S Balasubramanian
Recent Res. Devel. in Organic Chem. 2, 367-379 (1998) - The Synthesis and Hybridisation Properties of a Library of Oligonucleotide-Peptide Conjugates
J G Harrison and S Balasubramanian
Nucleic Acids Research, 26, 3136-3145 (1998) - Optically Biased Diffusion of Single Molecules Studied by Confocal Fluorescence Microscopy
M A Osbourne, S Balasubramanian, W S Furey and D Klenerman
J. Phys. Chem. B, 102, 3160-3167 (1998) - Use of Fluorescence Resonance Energy Transfer to Investigate the Conformation of DNA Substrates Bound to the Klenow Fragment
W S Furey, C M Joyce, M A Osbourne, D Klenerman, J A Peliska and S Balasubramanian
Biochemistry, 37, 2979-2990 (1998) - A Combinatorial Approach to Identifying Protein Tyrosine Phosphatase Substrates from a Phosphotyrosine peptide Library
Y W Cheung, C Abell and S Balasubramanian
J. Am. Chem. Soc., 119, 9568-9569. (1997) - Synthesis of 2-Oxindole Derivatives via the Intramolecular Heck Reaction on Solid Support
V Arumugam, A Routledge, C Abell and S Balasubramanian
Tetrahedron Lett., 38, 6473-6476 (1997) - Studies on the Synthesis, Characterisation and Reactivity of Aromatic Diboronic Acids
M H Todd, S Balasubramanian and C Abell
Tetrahedron Lett., 38, 6781-6784 (1997) - Properties of Fluorophores on Solid Phase Resins; Implications for Screening, Encoding and Reaction Monitoring
R H Scott and S Balasubramanian
Bioorg. Med. Chem. Lett., 7, 1567-1572 (1997) - A Convenient Synthetic Route to Oligonucleotide Conjugates
J G Harrison and S Balasubramanian
Bioorg. Med. Chem. Lett., 7, 1041-1046 (1997) - An Investigation into Solid-Phase Radical Chemistry - Synthesis of Furan Rings
A Routledge, C Abell and S Balasubramanian
SynLett, 61-62 (1997) - The Use of a Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid-Phase Synthesis
A Routledge, C Abell and S Balasubramanian
Tetrahedron Lett., 38, 1227-1230 (1997) - Solid Phase Reductive Alkylation of Secondary Amines
N K Khan, V Arumugam and S Balasubramanian
Tetrahedron Lett., 37, 4819-4822 (1996) - The Mechanism of Metal Independent Hydroxylation by Chromobacterium violaceum Phenylalanine Hydroxylase
R T Carr, S Balasubramanian, P Hawkins and S J Benkovic
Biochemistry, 34, 7525-7532 (1995) - Escherichia coli Chorismate Synthase Catalyses the Conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate
S Bornemann, M K Ramjee, S Balasubramanian, C Abell, J R Coggins, D J Lowe and R N F Thorneley
J. Biol. Chem., 270, 22811-22815 (1995) - Observation of a Secondary Tritium Isotope Effect in the Reaction Catalyzed by Neurospora Crassa Chorismate Synthase
S Balasubramanian, J R Coggins and C Abell
Biochemistry, 34, 341-348 (1995) - Escherichia coli Chorismate Synthase: A Deuterium Kinetic Isotope Effect Under Single Turnover and Steady State Conditions shows that a Flavin Intermediate forms before the C-(6proR)-H bond is cleaved
S Bornemann, S Balasubramanian, J R Coggins, C Abell, D J Lowe and R N F Thorneley
Biochem. J., 305, 707-710 (1995) - Recombinant HIV-1 Nucleocapsid Protein Accelerates HIV-1 Reverse Transcriptase Catalyzed DNA Strand Transfer Reactions and Modulates RNase H Activity
J A Peliska, S Balasubramanian, D P Giedroc and S J Benkovic
Biochemistry, 33, 13817-13823 (1994) - Identification of Metal Ligands in Cu(II) Inhibited Chromobacterium violaceum Phenylalanine Hydroxylase by Electron Spin Echo Envelope Modulation Analysis of Histidine to Serine Mutations
S Balasubramanian, R T Carr, C J Bender, J Peisach and S J Benkovic
Biochemistry, 33, 8532-8537 (1994) - Studies on Escherichia coli Chorismate Synthase
S Borneman, M N Ramjee, D J Lowe, R N F Thorneley, J R Coggins, C Abell, S Balasubramanian, T R Hawkes, W W Nichols and G M Davies
Flavins and Flavoproteins, (Ed. K. Yagi) 843-846. Walter de Gruyer, Berlin, New York (1994) - Histidines 138 and 143 are Copper Binding Ligands in Chromobacterium violaceum Phenylalanine Hydroxylase
S Balasubramanian, R T Carr, C J Bender, J Peisach and S J Benkovic
Chemistry and Biology of Pteridines and Folates, Eds. J.E. Ayling, M.G. Nair, and C.M. Baugh 67-71 (1993) - Reaction of (6R)-6-F-EPSP with Recombinant Escherichia coli Chorismate Synthase Generates a Stable Flavin Mononucleotide Semiquinone Radical
M N Ramjee, S Balasubramanian, C Abell, J R Coggins, G M Davies, T R Hawkes, D J Lowe and R N F Thorneley
J. Am. Chem. Soc., 114, 3151-3153 (1992) - Inhibition of Chorismate Synthase by (6R)- and (6S)-6-Fluoro-5-enolpyruvylshikimate 3-Phosphate
S Balasubramanian, G M Davies, J R Coggins and C Abell
J. Am. Chem. Soc., 113, 8945-8946 (1991) - The Synthesis of (6R)-[6-2H]- and (6S)-[6-2H]5-Enolpyruvylshikimate 3-Phosphate
S Balasubramanian and C Abell
Tetrahedron Lett., 32, 963-966 (1991) - Observation of an Isotope Effect in the Chorismate Synthase Reaction
S Balasubramanian, C Abell and J R Coggins
J. Am. Chem. Soc., 112, 8581-8583 (1990)
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